Table 3 Pathways regulated within the oviduct and uterus, and target genes of differentially expressed miRNAs on the OF- or UF-EVs¹

Endocytosis

Total

59 genes

14 genes

177 genes

141 genes

Exclusively modulated

3 (FAM21A, LOC616942, HSPA1A)

1 (AP2A2)

42 (CCR5, CAPZA2, ARPC1B, ARF3, VPS25, MVB12A, AP2M1, ARPC2, VPS28, VTA1, BOLA, RAB4A, HGS, SNX6, CAV3, SNF8, CHMP6, STAMBP, AP2S1, USP8, RAB5A, SNX4, TSG101, CBLC, RAB8A, AP2A1, EHD4, RAB11FIP2, VPS26B, PRKCI, TFRC, CLTB, CXCR4, GRK5, HSPA8, IGF2R, SPG21, PIP5K1B, WASHC5, GRK4, ARAP1, IZUMO1R)

14 (VPS29, RAB11B, CHMP2B, JSP1, FOLR2, CYTH2, SPART, SNX3, ACAP2, BoLA, PSD, FGFR4, ARRB2, FOLR3)

Ras signaling

Total

56 genes

12 genes

0 genes

145 genes

Exclusively modulated

1 (PLA2G12B)

1 (KSR)

30 (PLA2G2D1, STK4, PLA2G4A, FGF18, PAK4, RAB5A, IGF1, RRAS2, RAC3, RASAL3, MAP2K1, RASGRP1, CALM, FGF20, RIN1, GNB3, PLA2G4F, FGF16, EXOC2, PAK2, CALM2, IKBKB, IKBKG, VEGFB, VEGFC, PIK3R2, LOC615045, PLA2G2C, LOC786717, LOC789148)

14 (PLA1A, PLA2G16, PRKCG, INS, FGFR4, TBK1, EPHA2, PIK3CB, GNG2, PLCG1, PRKCA, RASA1, LOC521224, SHC2)

Insulin signaling

Total

8 genes

35 genes

101 genes

87 genes

Exclusively modulated

1 (PDPK)

0

23 (HK1, RHEB, PPP1CA, PKLR, PRKAR1A, EIF4EBP1, LIPE, PTPN1, PRKAA1, MAP2K1, CALM, INPP5J, ACACB, PPP1R3A, PRKCI, CALM2, IKBKB, PIK3R2, PCK1, MTOR, PHKA1, HK2, PRKAG2)

9 (FLOT1, INS, PHKA2, GYS2, RPS6KB2, PIK3CB, G6PC3, TSC2, SHC2)

Wnt signaling

Total

0 genes

9 genes

118 genes

97 genes

Exclusively modulated

0

0

30 (WNT2, PRICKLE3, SFRP2, MYC, SFRP4, WIF1, CTNNB1, DAAM1, DKK2, PPARD, MAPK10, CSNK1B, RAC3, FZD1, PORCN, NFATC4, ROR2, PLCB4, RNF43, AXIN1, AXIN2, SIAH1, GPC4, PPP3R1, CSNK2A1, CSNK1A1, APC2, RYK, EP300, CTBP1)

8 (WNT16, CAMK2D, RSPO3, WNT10A, CREBBP, PRKCG, PRKCA, LOC780968)

Regulation of actin cytoskeleton

Total

51 genes

0 genes

153 genes

126 genes

Exclusively modulated

1 (MYL2)

0

30 (ARPC1B, PFN1, GSN, ARPC2, PPP1CA, ACTN1, FGF18, PAK4, PFN3, MYLK2, RRAS2, RAC3, ITGB7, MAP2K1, FGF20, DIAPH3, FGF16, CYFIP1, PAK2, LPAR1, CXCR4, ITGAV, ITGB1, PIK3R2, ITGA4, ITGB2, APC2, PIP5K1B, ARHGEF1, PPP1R12C)

4 (INS, FGFR4, ITGB4, PIK3CB)