Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

Table 2 Relative level of differentially expressed miRNAs in OF-EVs and UF-EVs (n = 3)¹

microRNA	OF-EVs (Mean ± SEM)	UF-EVs (Mean ± SEM)	P-value	log₂(Fold change)
bta-miR-148b	0.0018 ± 0.0004	0.0007 ± 0.0001	≤ 0.038	–1.4065
bta-miR-134	0.0013 ± 0.0002	0.0074 ± 0.0013	≤ 0.001	2.4870
bta-miR-151-3p	0.0035 ± 0.0004	0.0065 ± 0.0005	≤ 0.012	0.9047
bta-miR-155	0.0006 ± 0.0001	0.0015 ± 0.0003	≤ 0.037	1.3253
bta-miR-188	0.0026 ± 0.0002	0.0048 ± 0.0006	≤ 0.024	0.9014
bta-miR-181b	0.0025 ± 0.0003	0.0060 ± 0.0007	≤ 0.004	1.2652
bta-miR-181d	0.0054 ± 0.0003	0.0107 ± 0.0010	≤ 0.005	0.9930
bta-miR-224	0.0004 ± 0.0001	0.0052 ± 0.0019	≤ 0.005	3.7966
bta-miR-23b-3p	0.0042 ± 0.0012	0.0242 ± 0.0070	≤ 0.022	2.5391
bta-miR-24-3p	0.0012 ± 0.0003	0.0053 ± 0.0016	≤ 0.029	2.1562
bta-miR-27a-3p	0.0005 ± 0.0002	0.0031 ± 0.0004	≤ 0.030	2.6102
bta-miR-29a	0.0036 ± 0.0004	0.0061 ± 0.0003	≤ 0.038	0.7838
bta-miR-324	0.0009 ± 0.0002	0.0035 ± 0.0009	≤ 0.029	2.0001
bta-miR-326	0.0032 ± 0.0006	0.0143 ± 0.0047	≤ 0.046	2.1404
bta-miR-345-3p	0.0011 ± 0.0001	0.0044 ± 0.0015	≤ 0.048	1.9707
bta-miR-410	0.0007 ± 0.0001	0.0011 ± 0.0001	≤ 0.028	0.6311
bta-miR-652	0.0011 ± 0.0001	0.0024 ± 0.0005	≤ 0.042	1.1760
bta-miR-677	0.0040 ± 0.0005	0.0100 ± 0.0012	≤ 0.005	1.3403
bta-miR-873	0.0003 ± 0.0001	0.0009 ± 0.0001	≤ 0.021	1.7507
bta-miR-708	0.0005 ± 0.0001	0.0013 ± 0.0003	≤ 0.024	1.2640

¹Fold changes were calculated as the ratio of the mean expression level of UF-EVs/OF-EVs

ISSN: 2049-1891