Fig. 9
Network of lipid metabolism genes modulated by miRNAs differentially expressed between OF-EVs and UF-EVs. A Selected LMGs found to be modulated by differently expressed miRNAs (PPARGC1B, CD36, LDLR, PNPLA2, ELOVL6, FASN, and ELOVL5). B Networks of miRNAs and genes related with the uptake of lipids. C Networks of miRNAs and genes related with the transport of lipid. D Networks of miRNAs and genes related to the synthesis of lipids. E Networks of miRNAs and genes related with accumulation of lipid droplets. F Networks of miRNAs and genes related to lipolysis. Continuous lines indicate a direct relationship, while dashed lines indicate an indirect relationship. Networks were generated by QIAGEN Ingenuity Pathway Analysis software and only experimentally observed relationships were selected