Fig. 1

miRNAs profile of OF-EVs and UF-EVs. A Venn diagram representing the 333 miRNAs detected: 263 in common between the two groups, 11 exclusives to OF-EVs, and 59 exclusive to UF-EVs. B miRNA (bta-miR-148b) up-regulated in OF-EVs. C miRNAs (bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) up-regulated in UF-EVs. ^a,bDifferent letters indicate miRNAs with relative expression significantly different (P < 0.05) between the groups. Error bars represent SEM