Fig. 2
From: tRNAGlu-derived fragments from embryonic extracellular vesicles modulate bovine embryo hatching
Inhibition of tDR-14:32-Glu-CTC-1 during preimplantation embryo development improves embryo hatching. A Fluorescence imaging showed tRF agomirs were taken up by embryos, BF: Bright-field, FAM: 5-Carboxyfluorescein. B Embryo developmental rates of bovine embryos treated with tDR-14:32-Glu-CTC-1 agomir. C Embryo developmental rates of bovine embryos treated with tDR-14:32-Glu-CTC-1 antagomir. D Hierarchical clustering and heatmap of DEGs between control group and tDR-14:32-Glu-CTC-1 antagomir group. E GO-Cellular Component terms enrichment of DEGs between control group and tDR-14:32-Glu-CTC-1 antagomir group. F Gene set enrichment analysis (GSEA) combined with the KEGG gene sets showed the lysosome pathway is up-regulated in tDR-14:32-Glu-CTC-1 antagomir group. G GSEA using the GO database showed the desmosome pathway is down-regulated in the antagomir group. Error bars represent SE. *P < 0.05, **P < 0.01