Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

Table 4 Effect of maternal MET supplementation on plasma amino acid composition of neonatal piglets

Item	Treatments				SEM	P-value
Item	CON_IUGR	CON_NBW	MET_IUGR	MET_NBW	SEM	BW	MET	BW × MET
Essential amino acids, nmol/mL
Lys	390.21^a	205.11^b	305.91^ab	363.69^a	27.55	0.02	0.18	< 0.01
Met	36.38	26.00	20.96	26.95	6.27	0.66	0.23	0.23
Thr	316.97^a	155.33^c	185.78^bc	226.73^b	20.11	0.02	0.24	< 0.01
Val	265.95	282.08	246.00	273.10	12.45	0.11	0.28	0.68
Ile	54.28^a	36.21^b	28.63^b	31.09^b	5.94	0.22	0.02	0.11
Leu	122.00	66.90	108.75	115.05	10.35	0.22	0.37	0.12
Phe	98.93^a	69.75^b	72.09^b	84.30^ab	9.82	0.38	0.52	0.04
Trp	1.24	0.73	0.98	0.63	0.31	0.28	0.22	0.56
His	58.50^b	20.63^c	54.32^b	81.13^a	4.63	0.48	< 0.01	< 0.01
Arg	18.73	42.95	19.88	26.61	9.75	0.13	0.45	0.39
Non essential amino acids, nmol/mL
Glu	264.83	150.13	190.99	225.98	24.57	0.96	0.82	0.09
Gly	1,662.69^a	1,289.57^bc	1,192.03^c	1,544.49^ab	160.35	0.93	0.34	< 0.01
Ala	1,062.73^a	786.88^bc	682.09^c	860.06^b	28.16	0.38	< 0.01	< 0.01
Cit	138.83	123.04	103.31	128.10	21.07	0.83	0.48	0.34
Ser	317.18^a	215.60^b	223.35^b	238.63^b	25.34	0.02	0.04	< 0.01
Cys	12.18^bc	42.45^a	15.71^b	4.56^c	2.96	0.02	< 0.01	< 0.01
Tyr	92.72	47.08	68.27	61.35	15.50	0.07	0.71	0.17
Orn	155.89^a	78.90^b	98.64^b	168.45^a	13.06	0.80	0.27	< 0.01
Pro	276.75^a	185.08^b	185.21^b	265.75^a	20.67	0.83	0.84	< 0.01
Tau	288.55^a	178.99^b	167.63^b	236.45^ab	31.64	0.52	0.32	< 0.01
Asp	53.33^ab	32.35^b	56.55^a	46.97^ab	1.52	0.05	0.24	0.45
Urea	5,103^a	3,673^b	2,864^c	3,394^bc	310.46	0.07	< 0.01	< 0.01
Total	12,175^a	9,792^bc	8,535^c	10,108^b	341.19	0.48	< 0.01	< 0.01

CON_IUGR CON group with IUGR piglets, CON_NBW CON group with NBW piglets, MET_IUGR MET group with IUGR piglets, MET_NBW MET group with NBW piglets
^a–cP < 0.05 between different superscripts within the same line, n = 10 in each group

ISSN: 2049-1891