Table 2 Chemical compounds-induced oxidative stress models in swine
Swine models | Body weight, kg | Inducer and duration | Changes in oxidative indicators | References |
|---|---|---|---|---|
Weaned piglets | 9.92 ± 0.3 | Diquat 10 mg/kg, 7 d | Serum: T-AOC (2.5 → 2.1 U/L) ↓ MDA (2.8 → 4.5 nmol/L) ↑ | [57] |
10.63 ± 1 | Diquat 10 mg/kg, 7 d (From 35 to 42 days of age) | Serum: SOD (74.8 ± 1.5 → 56.14 ± 1.58 U/mL) ↓ CAT (10.35 ± 0.53 → 8.97 ± 0.34 U/mL) ↓ GPx (493.62 ± 30.95 → 313.56 ± 48.67 U/mL) ↓ MDA (2.76 ± 0.07 → 3.32 ± 0.11 mmol/L) ↑ | [58] | |
Average 9.6 | Diquat 10 mg/kg, 7 d (From 35 to 42 days of age) | Jejunum: SOD (100.32 ± 11.29 → 60.06 ± 8.01 U/mg protein) ↓ GPx (99.35 ± 8.31 → 57.88 ± 6.4 U/mg protein) ↓ MDA (0.54 ± 0.07 → 1.91 ± 0.1 nmol/g protein) ↑ Mitochondrial ROS (9 times higher than control) ↑ | [59] | |
10.96 ± 0.61 | H2O2 1 mg/kg, 7 d | Serum: MDA (3.8 → 4.5 ng/mL) ↑ H2O2 (20 → 28 mmol/L) ↓ | [60] | |
11.58 ± 0.26 | LPS 100 μg/kg, 3 h (On 35 days of age) | Serum: SOD (110.6 ± 6.9 → 98.3 ± 5.8 U/mL) ↓ CAT (4.75 ± 0.51 → 4.1 ± 0.36 U/mL) ↓ GPx (396.6 ± 18.5 → 359.4 ± 36.8 U/mL) ↓ H2O2 (51.28 ± 8.09 → 65.05 ± 8.46 mol/L) ↑ MDA (5.63 ± 0.46 → 6.59 ± 1 mmol/L) ↑ | [61] | |
Average 9.8 | LPS 100 μg/kg, 7 d (From 35 to 42 days of age) | Jejunum: SOD (95.85 ± 3.13 → 63.12 ± 2.97 U/mg protein) ↓ GPx (72.11 ± 3.51 → 53.99 ± 3.26 U/mg protein) ↓ MDA (0.95 ± 0.16 → 1.51 ± 0.25 nmol/g protein) ↑ Mitochondrial ROS (8 times higher than control) ↑ | [62] | |
6.65 ± 1.19 | LPS 100 μg/kg, 5 d (From 31 to 36 days of age) | Serum: T-AOC (0.21 ± 0.008 → 0.16 ± 0.025 mmol/L) ↓ SOD (27.73 ± 1.19 → 24.73 ± 1.59 U/mL) ↓ GPx (317.2 ± 28.96 → 245.63 ± 21.37 U/mL) ↓ | [63] | |
100-day-old male miniature pigs | 21.73 ± 0.43 | CTX 50 mg/kg, 7 d | Serum: SOD (27 → 8 U/L) ↓ GPx (420 → 220 μmol/L) ↓ MDA (12 → 1.51 ± 24 μmol/L) ↑ | [64] |