Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa

Table 4 Relative mRNA expression of tight junction proteins, pro-inflammatory cytokines and intestinal alkaline phosphatase in distal small intestinal mucosa of piglets fed diets with or without mycotoxin contamination, and with or without binder at d14 post-weaning (n = 5)

Means with different superscripts (a, b) within row represent differences among treatments (P ≤ 0.05)
¹ CLDN-1 Claudin 1, CLDN-2 Claudin 2, CLDN-5 Claudin 5, CLDN-7 Claudin 7, IAP Intestinal alkaline phosphatase, IFN-γ Interferon, gamma, IL-1β Interleukin 1 beta, IL-8 Interleukin 8, OCLN Occludin, TLR-4 Toll like receptor 4, TNF-α Tumor necrosis factor alpha, ZO-1 Zona occludens 1, ZO-2 Zona occludens 2
² CON negative control diet (uncontaminated basal diet), CON + BIN negative control diet with 1 kg/t mycotoxin binder, DON negative control diet with DON, DON + BIN negative control diet with DON and 1 kg/t mycotoxin binder

ISSN: 2049-1891